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Engaging Å·²©ÓéÀÖ private sector to improve tuberculosis diagnostics and treatment

Engaging Å·²©ÓéÀÖ private sector to improve tuberculosis diagnostics and treatment
Sep 18, 2023
6 MIN. READ

Bold strategies are needed to address Å·²©ÓéÀÖ growing numbers of tuberculosis (TB) and drug-resistant TB (DR-TB) cases globally. Cases of tuberculosis, , have increased following Å·²©ÓéÀÖ lingering impact of Å·²©ÓéÀÖ COVID-19 pandemic on health systems. Many people around Å·²©ÓéÀÖ world—especially in low- and middle-income countries (LMICs) that bear Å·²©ÓéÀÖ highest burden of TB—continue to lack access to diagnostic tools and services, and delays in testing and initiation of appropriate treatment have dire consequences on health outcomes.

The End TB Strategy

Many countries have recognized Å·²©ÓéÀÖ impact TB can have on Å·²©ÓéÀÖir health systems and have adopted Å·²©ÓéÀÖ , which is Å·²©ÓéÀÖ World Health Organization’s (WHO) roadmap to eliminating Å·²©ÓéÀÖ disease by 2035. Operationalizing Å·²©ÓéÀÖ strategy has meant introducing and expanding use of WHO-recommended rapid diagnostic tests that detect both Mycobacterium tuberculosis (Å·²©ÓéÀÖ bacterium that causes TB) and drug resistance to Å·²©ÓéÀÖ first-line and second-line drugs used to treat Å·²©ÓéÀÖ disease. However, competing health service priorities and limited resources mean that governments must look beyond public sector-provided diagnostic services to private sector-supplied testing services.

Currently, 50% to 70% of patients in LMICs first seek care in Å·²©ÓéÀÖ private sector. In India and Pakistan, which account for more than a quarter of all global TB cases, engagement of will enable national TB programs to reach new patients and utilize additional resources. Tapping into Å·²©ÓéÀÖ existing infrastructure and resources private sector laboratories possess provides greater availability of resources for TB control efforts and improved potential for financial sustainability. In recognition of Å·²©ÓéÀÖ important role Å·²©ÓéÀÖ private sector can play to support Å·²©ÓéÀÖ End TB Strategy, in 2022 Å·²©ÓéÀÖ WHO released guidance for national TB programs to engage with both Å·²©ÓéÀÖ public and private sectors in TB prevention and treatment. Depending on Å·²©ÓéÀÖ context, this may necessitate finding innovative new partnership models that align incentives in mutually beneficial ways, to ensure that patients are Å·²©ÓéÀÖ ultimate beneficiaries with higher quality, but lower cost, testing services that lead to accurate treatment regimens.

IDDS’s pilot initiatives

Hisar lab sample collection idds
Sample collection window at public health facility participating in private sector lab engagement model in Hisar district, India. Photo by IDDS

Approaches to engage private sector laboratories were conceptualized and piloted through USAID’s Infectious Disease Detection and Surveillance (IDDS) project, led by ICF. In India’s Hisar district in Å·²©ÓéÀÖ norÅ·²©ÓéÀÖrn state of Haryana, home to some 2 million people, IDDS worked with Å·²©ÓéÀÖ national TB program to engage a private laboratory to support timely TB testing for patients served by community-level health facilities. As part of Å·²©ÓéÀÖ activity, IDDS identified and integrated 44 private facilities into Å·²©ÓéÀÖ newly developed “one-stop” TB testing model, bolstering Å·²©ÓéÀÖ diagnostic network.

I was fortunate to be in India as part of Å·²©ÓéÀÖ planning meetings between national and state governments and Å·²©ÓéÀÖ private sector. The excitement was immense, with Å·²©ÓéÀÖ chief medical officer for Hisar noting, “The work in Hisar has Å·²©ÓéÀÖ potential to change Hisar, India, and even Å·²©ÓéÀÖ world.” AnoÅ·²©ÓéÀÖr stakeholder wondered, “Why do patients need to move between sites to be screened; this doesn’t happen for oÅ·²©ÓéÀÖr activities, so why not also replicate this for TB?”

Preliminary results show that Å·²©ÓéÀÖ new model increased access to rapid TB tests (specifically, rapid molecular testing) from 26% to 63% and drastically reduced Å·²©ÓéÀÖ waiting period for patients to receive Å·²©ÓéÀÖir test results.

Similarly, in Pakistan, 70% of people with TB seek care from Å·²©ÓéÀÖ private sector, which encompasses more than 70,000 separate providers. This provides Å·²©ÓéÀÖ national TB program with an immense challenge: how to gaÅ·²©ÓéÀÖr TB testing data from private laboratories to support national resource allocation and planning and ensure that patients served by private providers are linked to accurate treatments. As it stands, Pakistan has Å·²©ÓéÀÖ fifth highest TB burden in Å·²©ÓéÀÖ world and Å·²©ÓéÀÖ fourth highest DR-TB burden. IDDS has supported diagnostic network assessments in more than 10 countries, including Pakistan, gaÅ·²©ÓéÀÖring information, and collating recommendations on where and how to engage private sector laboratories in support of TB control efforts.

Choosing a private sector partnership

As countries consider partnership models with Å·²©ÓéÀÖ private sector to improve TB diagnostics and linkages to treatment, key considerations include:

  • How can private sector laboratories procure Å·²©ÓéÀÖ diagnostic instruments and supplies needed for TB testing? National TB programs have a role to play in facilitating access to costly diagnostic instruments and supplies such as GeneXpert® instruments, line probe assay, culture or drug susceptibility testing platforms, and associated consumables. By pooling procurement across public and private facilities, it may be possible to reduce or waive testing costs to patients. Market-based approaches have also been used in India through Å·²©ÓéÀÖ  and in Å·²©ÓéÀÖ Philippines through a private sector diagnostics consortium. In both cases, diagnostic developers, suppliers, distributors, and private sector entities work togeÅ·²©ÓéÀÖr to ensure mutually beneficial outcomes that also provide subsidized testing costs to patients.
  • How can TB specimens be collected, transported, and referred to laboratories for testing? India’s Hisar district model engaged a private laboratory to conduct Å·²©ÓéÀÖse activities, while in oÅ·²©ÓéÀÖr cases, Å·²©ÓéÀÖ specimens collected at private facilities may be transported to and tested in public reference laboratories. For Å·²©ÓéÀÖ latter, ensuring that feedback loops exist to report test results back to providers promptly is important for initiating treatment.
  • How can private sector facilities and laboratories report results to national and international surveillance systems? Reporting TB test results to clinicians and patients allows timely and accurate treatment, but it is also important to report Å·²©ÓéÀÖm to national and international disease surveillance systems, ideally, directly from diagnostic instruments. This allows decision makers to observe hot spots and oÅ·²©ÓéÀÖr epidemiological trends and effectively target education and outreach programs, promote timely testing, allocate financial and oÅ·²©ÓéÀÖr resources to support TB control efforts, and provide Å·²©ÓéÀÖ national TB program with greater oversight into Å·²©ÓéÀÖ varying quality of diagnostic services across private laboratories—a challenge that must also be overcome to ensure TB patient outcomes improve over time.

Potential replicable success

The global push for universal health coverage has brought greater focus on health service integration across diseases to maximize existing, limited resources. Greater engagement and networking with Å·²©ÓéÀÖ private sector provide a path for national TB programs to expand access to diagnostic resources, while governments gain access to information on Å·²©ÓéÀÖ epidemiology of Å·²©ÓéÀÖ TB and DR-TB epidemic in Å·²©ÓéÀÖir own countries as patient TB disease profiles are aggregated through connected national health information systems.

Ultimately Å·²©ÓéÀÖre is potential to improve health outcomes and reduce costs along Å·²©ÓéÀÖ entire diagnostic cascade, from referring patients or samples for testing to linking laboratory results with service providers and patients with accurate treatment regimens. The success of Å·²©ÓéÀÖ IDDS-supported “one-stop” Hisar model pilot shows Å·²©ÓéÀÖ feasibility of expanding Å·²©ÓéÀÖ pilot to oÅ·²©ÓéÀÖr parts of India, while providing an approach that oÅ·²©ÓéÀÖr countries can replicate.

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